Structural, Dynamical, and Energetical Consequences of Rett Syndrome Mutation R133C in MeCP2

Table 2

Average number of hydrogen bonds formed with DNA (top) and water (bottom) computed over the course of the trajectories. Standard errors are omitted since they were negligibly small.

	WT	R133C
Average number of hydrogen bonds with DNA
Protein	7.21	5.70
Residue 133	0.63	0.0
Residue 111	0.74	0.66
Average number of hydrogen bonds with water
Protein	81.8	76.2
Residue 133	1.68	0.79
Residue 111	0.47	0.39
DNA	150	156
mC33	2.70	2.73
mC8	2.69	2.59