Nanodosimetry-Based Plan Optimization for Particle Therapy

Figure 5

Nanodsimetric quantities calculated for the optimized single-field proton plans as a function of the voxel depth. Results of the uniform optimization and uniform cluster yield optimization are shown in the left and right columns, respectively. (a), (b) Composite . (c), (d) Composite (squares) and (triangles). (e) Frequency of small clusters (squares) and large clusters (triangles) relative to the total yield . (f) Composite .

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