A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator

Table 1

HIV host genetic factor genes.

Gene symbol	Gene ID	Effect
APOBEC3B	9582	Increase infection
APOBEC3G	60489	Accelerates AIDS
CCL11	6356
CCL17	6361
CCL18	6362
CCL2	6347
CCL4	6351
CCL5	6352
CUL5	8065	Accelerates CD4 loss
CXCR1	3577
CXCR6	10663	Accelerates AIDS
DC-SIGN	30835	Decreases infection
DEFB1	1672
GML	2765
HCP5	10866	HIV set point
HLA-A	3105	Delays AIDS
HLA-B	3106	Delays AIDS
HLA-C	3107	Delays AIDS
IDH1	3417	Prevents infection
IFENG	3458	Accelerates AIDS
IL10	3586	Accelerates AIDS
IL4	3565
IRF1	3659
KIR	2669	Delays AIDS
LY6D	8581
MYH9	4627	End stage renal disease
NCOR2	9612	Increase infection
PECI/ECI2	10455	Accelerates AIDS
PPIA/CypA	5478	Accelerates AIDS
PROX1	5629	Delays AIDS progression
SDF1/CXCL12	6387	Delays AIDS
Slurp1	57152
Slurp2/Ly6	6004
TLR4	7099
TLR8	51311
TLR9	54106
TRIM5a	85363	Increase infection
TSG101	7251	Accelerates AIDS
ZNRD1	30834