A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator

Table 2

Human metabolism pathway for KEGG.

Pathway name	KEGG ID	Class of metabolism pathway	Gene number
Glycolysis/gluconeogenesis	10	Carbohydrate metabolism	67
Citrate cycle (TCA cycle)	20	Carbohydrate metabolism	31
Pentose phosphate pathway	30	Carbohydrate metabolism	29
Pentose and glucuronate interconversions	40	Carbohydrate metabolism	34
Fructose and mannose metabolism	51	Carbohydrate metabolism	36
Galactose metabolism	52	Carbohydrate metabolism	30
Ascorbate and aldarate metabolism	53	Carbohydrate metabolism	27
Starch and sucrose metabolism	500	Carbohydrate metabolism	56
Amino sugar and nucleotide sugar	520	Carbohydrate metabolism	49
Pyruvate metabolism	620	Carbohydrate metabolism	42
Glyoxylate and dicarboxylate metabolism	630	Carbohydrate metabolism	24
Propanoate metabolism	640	Carbohydrate metabolism	32
Butanoate metabolism	650	Carbohydrate metabolism	29
Inositol phosphate metabolism	562	Carbohydrate metabolism	61
Oxidative phosphorylation	190	Energy metabolism	133
Nitrogen metabolism	910	Energy metabolism	27
Sulfur metabolism	920	Energy metabolism	18
Fatty acid biosynthesis	61	Lipid metabolism	6
Fatty acid elongation	62	Lipid metabolism	23
Fatty acid metabolism	71	Lipid metabolism	44
Ketone bodies	72	Lipid metabolism	9
Steroid biosynthesis	100	Lipid metabolism	18
Primary bile acid biosynthesis	120	Lipid metabolism	17
Steroid hormone biosynthesis	140	Lipid metabolism	56
Glycerolipid metabolism	561	Lipid metabolism	55
Glycerophospholipid metabolism	564	Lipid metabolism	91
Ether lipid metabolism	565	Lipid metabolism	42
Sphingolipid metabolism	600	Lipid metabolism	47
Arachidonic acid metabolism	590	Lipid metabolism	68
Linoleic acid metabolism	591	Lipid metabolism	33
Alpha-linolenic acid metabolism	592	Lipid metabolism	25
Biosynthesis of unsaturated fatty acids	1040	Lipid metabolism	21
Purine metabolism	230	Nucleotide metabolism	173
Pyrimidine metabolism	240	Nucleotide metabolism	107
Alanine, aspartate, and glutamate metabolism	250	Amino acid metabolism	32
Glycine, serine, and threonine metabolism	260	Amino acid metabolism	37
Cysteine and methionine metabolism	270	Amino acid metabolism	34
Valine, leucine, and isoleucine degradation	280	Amino acid metabolism	44
Valine, leucine, and isoleucine biosynthesis	290	Amino acid metabolism	2
Lysine biosynthesis	300	Amino acid metabolism	2
Lysine degradation	310	Amino acid metabolism	49
Arginine and proline metabolism	330	Amino acid metabolism	57
Histidine metabolism	340	Amino acid metabolism	28
Tyrosine metabolism	350	Amino acid metabolism	39
Phenylalanine metabolism	360	Amino acid metabolism	18
Tryptophan metabolism	380	Amino acid metabolism	40
Phenylalanine, tyrosine, and tryptophan biosynthesis	400	Amino acid metabolism	5
Beta-alanine metabolism	410	Metabolism of other amino acids	29
Taurine and hypotaurine metabolism	430	Metabolism of other amino acids	10
Selenocompound metabolism	450	Metabolism of other amino acids	17
Cyanoamino acid metabolism	460	Metabolism of other amino acids	7
D-Glutamine and D-glutamate metabolism	471	Metabolism of other amino acids	4
D-Arginine and D-ornithine metabolism	472	Metabolism of other amino acids	1
Glutathione metabolism	480	Metabolism of other amino acids	51
N-Glycan biosynthesis	510	Glycan biosynthesis and metabolism	49
Mucin type O-glycan biosynthesis	512	Glycan biosynthesis and metabolism	31
Other types of O-glycan biosynthesis	514	Glycan biosynthesis and metabolism	30
Glycosaminoglycan biosynthesis, chondroitin sulfate/dermatan sulfate	532	Glycan biosynthesis and metabolism	20
Glycosaminoglycan biosynthesis, heparan sulfate/heparin	534	Glycan biosynthesis and metabolism	24
Glycosaminoglycan biosynthesis, keratan sulfate	533	Glycan biosynthesis and metabolism	15
Glycosaminoglycan degradation	531	Glycan biosynthesis and metabolism	19
Glycosylphosphatidylinositol- (GPI-) anchor biosynthesis	563	Glycan biosynthesis and metabolism	25
Glycosphingolipid biosynthesis, lacto- and neolactoseries	601	Glycan biosynthesis and metabolism	26
Glycosphingolipid biosynthesis, globoseries	603	Glycan biosynthesis and metabolism	14
Glycosphingolipid biosynthesis, ganglioseries	604	Glycan biosynthesis and metabolism	15
Other glycan degradation	511	Glycan biosynthesis and metabolism	18
Thiamine metabolism	730	Metabolism of cofactors and vitamins	4
Riboflavin metabolism	740	Metabolism of cofactors and vitamins	13
Vitamin B6 metabolism	750	Metabolism of cofactors and vitamins	6
Nicotinate and nicotinamide metabolism	760	Metabolism of cofactors and vitamins	28
Pantothenate and CoA biosynthesis	770	Metabolism of cofactors and vitamins	17
Biotin metabolism	780	Metabolism of cofactors and vitamins	3
Lipoic acid metabolism	785	Metabolism of cofactors and vitamins	3
Folate biosynthesis	790	Metabolism of cofactors and vitamins	14
One carbon pool by folate	670	Metabolism of cofactors and vitamins	20
Retinol metabolism	830	Metabolism of cofactors and vitamins	68
Porphyrin and chlorophyll metabolism	860	Metabolism of cofactors and vitamins	43
Ubiquinone and other terpenoid-quinone biosynthesis	130	Metabolism of cofactors and vitamins	10
Terpenoid backbone biosynthesis	900	Metabolism of terpenoids and polyketides	21
Caffeine metabolism	232	Biosynthesis of other secondary metabolites	7
Butirosin and neomycin biosynthesis	524	Biosynthesis of other secondary metabolites	5
Metabolism of xenobiotics by cytochrome P450	980	Xenobiotics biodegradation and metabolism	80
Drug metabolism, cytochrome P450	982	Xenobiotics biodegradation and metabolism	74
Drug metabolism, other enzymes	983	Xenobiotics biodegradation and metabolism	51