Role of CaMKII and PKA in Early Afterdepolarization of Human Ventricular Myocardium Cell: A Computational Model Study

Figure 1

(a) No EAD was produced when CaMKII phosphorylation level was in control (CaMK₀ = 0.05). (b) Corresponding when no EADs occurred in (a). (c) Alternated EADs were produced when phosphorylation by CaMKII was enhanced with CaMK₀ of 0.12 and other targets’ phosphorylation levels were in control (CaMK₀ = 0.05). (d) Corresponding when alternated EADs occurred in (c). Under these conditions, CL was 2000 ms and was blocked by 85%.