Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study

Table 3

Seed-to-Voxel analysis. Statistically significant lower functional connectivity in patient group compared to controls.

Network	Seed regions	Target region	Coordinates	Cluster size	Cluster -FDR
Default Mode Network	Posterior cingulate cortex, bilateral	Frontal pole, right	(14, 62, 16)	96	0.016
		Middle temporal gyrus, right	(46, −40, 00)	74	0.029
		Superior frontal gyrus, left	(−08, 40, 48)	61	0.043
Task-Positive Network	Anterior intraparietal sulcus, bilateral	Premotor/primary; somatosensory cortex, left	(−48, −22, 52)	128	0.004
		Superior frontal gyrus, left	(−20, −08, 62)	102	0.008
		Lateral occipital cortex,; inferior division, left	(−42, −62, −08)	83	0.015
		Lateral occipital cortex, left	(−42, −62, 04)	61	0.044
Somatosensory Network	Primary somatosensory cortex, bilateral	Premotor/primary; somatosensory cortex, left	(−48, −16, 58)	227	<0.001
		Superior parietal lobule, left	(−32, −40, 54)	76	0.041

mm: Talairach space.