Modeling the Spatiotemporal Dynamics of Oncolytic Viruses and Radiotherapy as a Treatment for Cancer

Figure 1

Numerical simulations of (1) with the conditions (4) and (5) and parameter values from Table 1 ( is given in hours). For (a)–(c), the variables are plotted after the second, fourth, and sixth day of the treatment as indicated in the legend. In (d), the temporal evolution curve of the ratio of the uninfected cancer mass to its initial mass is plotted for a treatment that lasted 720 hours (30 days).

(a) Uninfected cell density

(b) Infected cell density

(c) Virus density

(d) The ratio of the uninfected cancer mass to its initial mass