Mathematical Modelling for the Role of CD4⁺T Cells in Tumor-Immune Interactions

Figure 5

Simulation of pulsed treatment case for first patient’s data: (a) 7 pulses of CD8⁺T cell treatment  = 10⁵ with 2 days period starting from day 6; (b) 7 pulses of IL-2 cytokine  = 10⁵ with 2 days period starting from day 6; (c) pulsed CD8⁺T cells and IL-2 treatment with initial tumor size T(0) = 8 × 10⁵; (d) pulsed CD8⁺T cells and IL-2 combined with CD4⁺T cell treatments with initial tumor size T(0) = 8×10⁵; (e) pulsed chemotherapy with initial tumor size T(0) = 3 × 10⁶; (f) pulsed chemotherapy combined with CD4⁺T cell treatment with initial tumor size T(0) = 3 × 10⁶; (g) pulsed chemotherapy combined with CD8⁺T cells and IL-2 treatments with initial tumor size T(0) = 10⁷; (h) pulsed chemotherapy combined with CD4⁺T cell treatment with initial tumor size T(0) = 10⁷.

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