Computational Study to Identify the Effects of the KCNJ2 E299V Mutation in Cardiac Pumping Capacity

Figure 1

Schematic diagram of electromechanical coupling for single-cell and three-dimensional simulations. The left side of the diagram is an electrophysiology simulation. The electrical components symbolize the currents, pumps, and ion exchangers of the cell membrane to mimic the cardiac cells, as suggested by Ten Tusscher et al. “I” represents the ion currents, and “E” represents the equilibrium potentials of each ion. The right side of the diagram shows mechanical simulations at the single-cell and the 3D ventricular heart levels. The mechanical components come from myofilament models proposed by Rice et al. Mechanical model at the 3D ventricular heart level is coupled with the circulatory system; “C” and “R” represent compliance and resistance of each structure, respectively; PA, pulmonary artery; PV, pulmonary vein; LA, left atrium; MI, mitral valve; LV, left ventricles; AO, aortic valve; SA, systemic artery; SV, systemic vein; RA, right atrium; TR, tricuspid valve; RV, right ventricles; PU, pulmonary valve; “P” and “V” are pressure and volume, respectively (for more details, see text).