Construction and Evaluation of a Tumor Mutation Burden-Related Prognostic Signature for Thyroid Carcinoma

Figure 4

Prognostic signature construction. (a) The coefficients of 33 survival-related genes in LASSO analysis changes as the penalty parameter lambda changes. (b) In the LASSO regression model, when the optimal lambda is adjusted, the number of genes with a nonzero coefficient is seven. (c) Multivariate Cox regression analysis for generation of the 5-gene prognostic signature. (d) Heat map of the expression of 5 feature genes in high- and low-risk groups. (e) The distribution chart of risk scores of patients with thyroid carcinoma (red represents high-risk group, and green represents low-risk group). (f) The distribution chart of survival of patients with different risk scores (red represents the dead patients, and green represents the surviving patients).

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