Identification of Pulpitis-Related Potential Biomarkers Using Bioinformatics Approach

Figure 4

The determination of pulpitis-related hub genes. (a) Venn diagram about node genes in PPI network and pulpitis-related genes. (b) Venn diagram of genes with RWR-analyzed affinity score at the top 50 and genes in key functional subset. (c) GeneMANIA database was employed to analyze the gene-gene interaction network (nodes in the inner circle represent hub genes while nodes in the outer circle indicate genes coexpressed with hub genes. Purple lines represent coexpression relationship, and the colors of the nodes indicate the biological functions in which the corresponding genes were enriched). (d–g) Expression of hub genes (CXCL10, CXCL1, CCL5, and CXCR4) in the pulpitis and normal pulp groups.

(a)

(b)

(c)

(d)

(e)

(f)

(g)