Prognostic and Therapeutic Significance of Circulating Tumor Cell Phenotype Detection Based on Epithelial-Mesenchymal Transition Markers in Early and Midstage Colorectal Cancer First-Line Chemotherapy

Table 2

Single factor analysis of PFS.

Variable	PFS
	Mean (months)	95% confidence interval		Chi-square	Log-rank value
		Lower bound	Upper bound
Age				0.038	0.845
≤55	18.21	13.725	22.685
>55	17.75	10.770	24.730
Gender				0.022	0.881
Male	18.51	13.342	23.683
Female	15.06	12.016	18.095
Lymph node metastasis				3.218	0.073
N0
N1
Degree of tumor				3.126	0.077
Low	14.58	9.357	19.803
Medium/high	21.88	17.979	25.771
Tumor size (cm)				1.126	0.289
≤4	14.58	11.447	22.286
>4	21.88	15.988	24.699
Total-CTCs -1/5 mL				0.177	0.674
≤3	18.735	14.011	23.459
>3	17.500	11.682	23.318
E-CTCs-1/5 mL				0.614	0.433
0	17.18	12.588	21.762
≥1	21.17	16.097	26.236
E/M-CTCs-1/5 mL				1.154	0.283
<2	10.45	8.088	12.818
≥2	19.67	15.488	23.858
M-CTCs-1/5 mL				0.987	0.320
0	16.66	11.923	21.399
≥1	21.17	16.097	26.236
Total-CTCs -2/5 mL				7.354	0.007
≤3	22.60	19.997	25.203
>3	11.07	6.835	15.311
E-CTCs-2/5 mL				4.591	0.032
0	20.41	16.802	24.017
≥1	11.25	4.232	18.268
E/M-CTCs-2/5 mL				2.181	0.140
<2	21.78	17.671	25.884
≥2	15.42	10.216	20.628
M-CTCs-2/5 mL				2.718	0.099
0	20.73	16.678	24.772
≥1	12.75	8.317	17.183
Dynamic of total CTCs				8.116	0.004
Decrease or unchanging
Increase
Dynamic of E-CTCs				1.659	0.198
Decrease or unchanging	19.41	15.573	23.254
Increase	12.67	2.859	22.474
Dynamic of E/M-CTCs				0.549	0.459
Decrease or unchanging	19.11	14.484	23.743
Increase	12.95	8.821	17.084
Dynamic of M-CTCs				5.937	0.015
Decrease or unchanging	21.30	17.887	24.713
Increase	11.33	6.035	16.632

(2-tailed); (2-tailed).