Computational and Mathematical Methods in Medicine

Research Article

Clinical Feature-Based Machine Learning Model for 1-Year Mortality Risk Prediction of ST-Segment Elevation Myocardial Infarction in Patients with Hyperuricemia: A Retrospective Study

Table 1

Comparison of characteristics of patients with and without mortality in the cohort.


Variables	Total ()	Survival ()	Death ()	value

Demographic characteristics
Sex, (%)				0.008
Female	107 (16)	83 (15)	24 (26)
Male	549 (84)	482 (85)	67 (74)
Age, y	64.00 (52, 74)	63.00 (51, 73)	70.00 (59, 78)	<0.001
Smoking, (%)	453 (69)	396 (70)	57 (63)	0.192
Weekend on admission, (%)	248 (38)	205 (36)	43 (47)	0.059
Delay, (%)	167 (25)	133 (24)	34 (37)	0.007
Vascular risk factors
Hypertension, (%)	380 (58)	326 (58)	54 (59)	0.857
Diabetes mellitus, (%)	121 (18)	98 (17)	23 (25)	0.096
Prior-stroke, (%)	35 (5)	30 (5)	5 (5)	1
CKD, (%)	152 (23)	122 (22)	30 (33)	0.024
Clinical data
HR, beats/min	80 (72, 92)	80.00 (72, 91)	85 (73, 106)	0.003
SBP, mmHg	124 (108, 140)	127 (110, 143)	111 (92, 129)	<0.001
DBP, mmHg	80 (68, 91)	80 (70, 92)	74 (58, 85)	<0.001
Shock_index	0.65 (0.55, 0.77)	0.64 (0.54, 0.75)	0.75 (0.61, 1.04)	<0.001
Electrocardiographic data
Inferior, (%)	300 (46)	263 (47)	37 (41)	0.351
Anterior, (%)	322 (49)	276 (49)	46 (51)	0.851
Other, (%)	21 (3)	16 (3)	5 (5)	0.194
Right ventricular, (%)	7 (1)	6 (1)	1 (1)	1
Laboratory examinations on admission
WBC, 10⁹/L	11.27 (8.60, 14.19)	10.97 (8.34, 13.57)	13.92 (10.56, 19.51)	<0.001
Neutrophil count, 10⁹/L	8.85 (6.34, 11.83)	8.46 (6.11, 11.19)	11.40 (8.43, 16.26)	<0.001
NLR	6.65 (3.89, 10.77)	6.25 (3.78, 9.85)	9.74 (5.89, 14.93)	<0.001
PLR	149.03 (104.31, 224.60)	148.96 (107.43, 220.27)	151.40 (81.96, 250.07)	0.518
MLR	0.54 (0.37, 0.82)	0.51 (0.36, 0.76)	0.75 (0.41, 1.12)	<0.001
SIRI	4.51 (2.63, 8.44)	4.19 (2.47, 7.39)	8.41 (4.38, 15.27)	<0.001
SII	1285.43 (746.84, 2247.28)	1233.05 (735.30, 2139.17)	1923.99 (894.50, 2898.80)	0.003
HB, g/L	139.00 (123.00, 154.00)	140.00 (124.00, 155.00)	128.00 (115.00, 147.00)	0.001
RBC, 10¹²/L	4.54 (3.98, 5.01)	4.58 (4.05, 5.02)	4.21 (3.71, 4.88)	0.006
PLT, 10⁹/L	205.00 (161.00, 249.25)	207.00 (164.00, 250.00)	196.00 (138.00, 246.50)	0.113
ALT, U/L	33.00 (23.00, 56.00)	32.00 (22.25, 51.75)	56.00 (30.00, 193.00)	<0.001
AST, U/L	72.00 (36.50, 169.5)	67.00 (35.00, 143.00)	225.00 (73.50, 456.00)	<0.001
GGT, U/L	44.00 (27.00, 75.00)	43.00 (27.00, 72.75)	61.00 (29.00, 104.00)	0.007
BUN, mmol/L	6.72 (5.25, 9.37)	6.38 (5.09, 8.50)	10.33 (7.45, 13.15)	<0.001
Creatinine, umol/L	101.00 (82.00, 128.00)	98.00 (81.00, 119.00)	134.00 (109.00, 174.50)	<0.001
Uric acid, umol/L	484.00 (449.00, 542.00)	481.00 (447.00, 535.00)	523.00 (461.00, 637.00)	<0.001
Cystatin C, mg/L	1.22 (0.97, 1.58)	1.17 (0.95, 1.49)	1.65 (1.32, 2.18)	<0.001
CK, U/L	507.00 (186.00, 1368.75)	463.50 (172.00, 1322.50)	745.00 (303.25, 2012.50)	0.002
CKMB, U/L	52.00 (25.00, 127.00)	48.00 (24.00, 117.25)	86.00 (33.00, 190.00)	<0.001
LDH, U/L	375.00 (266.25, 639.75)	350.50 (255.25, 556.75)	695.50 (407.75, 1229.75)	<0.001
α-HBDH, U/L	259.00 (173.00, 475.00)	240.00 (165.00, 427.50)	490.50 (273.75, 773.00)	<0.001
CTnT, ng/L	1014.00 (213.50, 3480.00)	786.95 (185.97, 3069.00)	3077.00 (1133.00, 6711.00)	<0.001
BNP, pg/mL	1022.50 (255.15, 3860.75)	884.90 (204.85, 2713.00)	5349.00 (2058.00, 15267.00)	<0.001
Glucose, mmol/L	6.66 (5.56, 8.66)	6.52 (5.44, 8.19)	8.47 (6.41, 11.60)	<0.001
Myoglobin, ng/mL	341.10 (104.50, 910.40)	308.95 (95.96, 820.28)	615.00 (203.50, 2251.00)	<0.001
Diseased vessel identified during procedure
LM, (%)	13 (2)	13 (2)	0 (0)	0.233
LAD, (%)	213 (33)	185 (33)	28 (31)	0.836
LCX, (%)	70 (11)	62 (11)	8 (9)	0.674
RCA, (%)	157 (24)	134 (24)	23 (26)	0.819
Risk assessment
GRACE, score	125.00 (102.00, 154.00)	121.00 (101.00, 146.00)	178.00 (140.00, 206.50)	<0.001

Values are expressed as medians with interquartile ranges for continuous data. Other values are presented as numbers and percentages. Shock index: ratio of HR to SBP; SIRI: systemic inflammatory response index; SII: systemic inflammatory reaction index; PLR: ratio of platelets to lymphocytes; NLR: the ratio of neutrophils to lymphocytes; MLR: ratio of monocytes to lymphocytes; OHCA: out-of-hospital cardiac arrest; GRACE: Global Registry of Acute Coronary Events score; α-HBDH: α-hydroxybutyrate dehydrogenase; BNP: B-type natriuretic peptides.