[Retracted] FAM87A as a Competing Endogenous RNA of miR-424-5p Suppresses Glioma Progression by Regulating PPM1H

Figure 6

FAM87A boosts the PPM1H expression by inhibiting miR-424-5p. (a) Volcano map of DEmRNAs in glioma. (b) Venn diagram of the intersection of target mRNAs of miR-424-5p and DEmRNAs predicted by the three databases (miRDB, TargetScan, and mirDIP). (c) Kaplan-Meier analysis for PPMIH. (d) Correlation analysis between miR-424-5p and the potential targets. (e) The expression of PPM1H in 76 glioma and adjacent tissues examined by qRT-PCR and correlation analysis of FAM87A and miR-424-5p. (f) PPM1H protein expression level in T98G and A172 cells after fostered FAM87A and miR-424-5p examined by western blot. (g) The binding relationship between PPM1H and miR-424-5p confirmed by dual-luciferase reporter gene assay. (h) T98G cell line used for RIP to detect the competitive binding of miR-424-5p between FAM87A and PPM1H. (i) The growth activity of T98G and A172 cells determined by MTT after PPM1H silencing. (j) Migration and invasion of T98G and A172 cells after PPM1H silencing detected by transwell (100×). (k) The influence of T98G and A172 cells on TMZ resistance after PPM1H silencing detected by MTT; and .

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