Elucidating the Mechanism of Action of Salvia miltiorrhiza for the Treatment of Acute Pancreatitis Based on Network Pharmacology and Molecular Docking Technology

Table 3

The information of the top 20 pathways in the KEGG pathway enrichment analysis.

No.	Pathway	Gene	value	Gene count
1	hsa05200: pathways in cancer	RB1, GSK3B, CDKN1A, GSTP1, PTGS2, ADCY8, RELA, EGFR, PIK3CG, CASP9, EDNRA, RXRA, CCND1, MYC, CASP3, ERBB2, AKT1, MAPK1, PRKACA, JUN, HSP90AA1, NOS2, MMP1, MMP2, STAT3, FOS, MMP9, VEGFA, NFKBIA, AR, IL6, CDK4, CDK2, BCL2, MDM2, BIRC5, PPARG, MET, TP53, BCL2L1	7.57E-20	44
2	hsa04080: neuroactive ligand-receptor interaction	CHRM2, OPRD1, CHRM3, PRSS1, CHRM1, CHRNA2, CHRM4, CHRNA7, CHRM5, HTR2C, ADRA1D, ADRB2, HTR2A, ADRA1B, NR3C1, ADRA1A, EDNRA, CALCR, DRD1, GABRE, DRD2, DRD5, GABRA2, GABRA1, GABRA6, GABRA5, HTR1A, HTR1B, OPRM1, ADRA2C, F2, GABRG3, ADRA2B, ADRA2A	3.64E-19	34
3	hsa05161: hepatitis B	RB1, CDKN1A, JUN, PCNA, STAT3, FOS, TNF, MMP9, PIK3CG, RELA, CASP9, NFKBIA, CCNA2, IL6, CCND1, CDK4, MYC, CASP3, CDK2, BCL2, BIRC5, AKT1, MAPK1, TP53	3.15E-16	24
4	hsa05219: bladder cancer	RB1, CDKN1A, MMP1, MMP2, MMP9, EGFR, VEGFA, CCND1, CDK4, MYC, ERBB2, MDM2, MAPK1, TP53	1.04E-13	14
5	hsa05215: prostate cancer	RB1, GSK3B, CDKN1A, HSP90AA1, EGFR, PIK3CG, RELA, CASP9, NFKBIA, AR, CCND1, ERBB2, CDK2, MDM2, BCL2, AKT1, MAPK1, TP53	1.17E-13	18
6	hsa04151: PI3K-Akt signaling pathway	CHRM2, GSK3B, CDKN1A, CHRM1, ITGB3, RELA, EGFR, PIK3CG, CASP9, RXRA, CCND1, MYC, AKT1, MAPK1, MCL1, HSP90AA1, NOS3, INSR, IL2, VEGFA, IL4, IL6, CDK4, CDK2, BCL2, MDM2, MET, TP53, BCL2L1	5.55E-12	29
7	hsa04066: HIF-1 signaling pathway	CDKN1A, EDN1, NOS2, NOS3, INSR, STAT3, EGFR, PIK3CG, RELA, VEGFA, IL6, IFNG, ERBB2, BCL2, AKT1, HMOX1, MAPK1	7.13E-12	17
8	hsa05222: small cell lung cancer	RB1, NOS2, PTGS2, PIK3CG, RELA, CASP9, NFKBIA, RXRA, CCND1, CDK4, MYC, CDK2, BCL2, AKT1, TP53, BCL2L1	1.43E-11	16
9	hsa05212: pancreatic cancer	RB1, STAT3, EGFR, PIK3CG, RELA, VEGFA, CASP9, CCND1, CDK4, ERBB2, AKT1, MAPK1, TP53, BCL2L1	6.79E-11	14
10	hsa05210: colorectal cancer	GSK3B, JUN, FOS, PIK3CG, CASP9, CCND1, MYC, CASP3, BCL2, BIRC5, AKT1, MAPK1, TP53	5.73E-10	13
11	hsa04024: cAMP signaling pathway	CHRM2, JUN, CHRM1, HTR1A, HTR1B, FOS, ADRB2, ADCY8, PIK3CG, RELA, NFKBIA, EDNRA, CAMK4, PDE3A, AKT1, MAPK1, DRD1, DRD2, PRKACA, DRD5	1.36E-09	20
12	hsa04915: estrogen signaling pathway	JUN, HSP90AA1, NOS3, MMP2, FOS, OPRM1, ADCY8, ESR1, MMP9, EGFR, PIK3CG, ESR2, AKT1, MAPK1, PRKACA	1.53E-09	15
13	hsa04725: cholinergic synapse	CHRM2, ACHE, CHRM3, CHRM1, CHRM4, CHRNA7, CHRM5, FOS, ADCY8, PIK3CG, CAMK4, BCL2, AKT1, MAPK1, PRKACA	7.09E-09	15
14	hsa04068: foxo signaling pathway	IL10, CDKN1A, INSR, STAT3, SLC2A4, MAPK14, EGFR, PIK3CG, IL6, CCNB1, CCND1, CDK2, MDM2, AKT1, MAPK1	8.18E-08	15
15	hsa04931: insulin resistance	NFKBIA, GSK3B, PTPN1, IL6, NOS3, INSR, STAT3, AKT1, SLC2A4, TNF, RELA, PIK3CG	2.80E-06	12
16	hsa04726: serotonergic synapse	CASP3, HTR1A, HTR1B, MAPK1, HTR2C, HTR3A, HTR2A, PRKACA, PTGS2, SLC6A4, PTGS1	2.42E-05	11
17	hsa05216: thyroid cancer	RXRA, CCND1, MYC, MAPK1, PPARG, TP53	1.36E-04	6
18	hsa04932: nonalcoholic fatty liver disease	GSK3B, IL6, CASP7, JUN, RXRA, CASP3, INSR, AKT1, TNF, RELA, PIK3CG	3.24E-04	11
19	hsa04152: AMPK signaling pathway	CCNA2, CCND1, FASN, INSR, AKT1, PPARG, SLC2A4, ADRA1A, PIK3CG	0.001461352	9
20	hsa05204: chemical carcinogenesis	CHRNA7, GSTP1, CYP1A2, CYP1A1, CYP3A4, PTGS2	0.013489355	7