[Retracted] NLRC4 Gene Single Nucleotide Polymorphisms Are Associated with the Prognosis of Hemophagocytic Lymphohistiocytosis
Table 3
Comparison of genotypes and allele frequencies at rs385076 locus and rs479333 locus of the NLRC4 gene in the death group and the survival group of HLH patients.
Death ()
Survive ()
RR (95% CI)#
rs385076
Genotype
TT
11 (50.00%)
36 (90.00%)
1.00 (reference)
TC
6 (27.27%)
2 (5.00%)
3.205 (1.277-4.788)
0.012
CC
5 (22.73%)
2 (5.00%)
3.052 (1.098-4.753)
0.031
Dominant model
3.133 (1.543-5.029)
0.001
Recessive model
2.311 (0.882-3.393)
0.091
Allele
T
27 (61.36%)
70 (87.50%)
1.00 (reference)
C
17 (38.64%)
10 (12.50%)
2.262 (1.359-3.347)
0.002
rs479333
Genotype
CC
9 (40.91%)
34 (85.00%)
1.00 (reference)
CG
8 (36.36%)
3 (7.50%)
3.475 (1.488-5.775)
0.003
GG
5 (22.73%)
3 (7.50%)
2.986 (1.014-5.570)
0.047
Dominant model
3.269 (1.580-6.092)
0.001
Recessive model
1.985 (0.741-3.250)
0.188
Allele
C
26 (59.09%)
71 (88.75%)
1.00 (reference)
G
18 (40.91%)
9 (11.25%)
2.487 (1.518-3.607)
<0.001
RR: relative risk; CI: confidence interval. #Adjusted the age, gender, BMI, history of hypertension, diabetes, coronary heart disease, and EBV infection of HLH patients.
