[Retracted] lncRNA MSC-AS1/miRNA-429 Axis Mediates Growth and Metastasis of Nasopharyngeal Carcinoma via JAK1/STAT3 Signaling Pathway

Figure 6

MSC-AS1 sponging miR-429 accelerates NPC progression via the JAK1/STAT3 pathway. (a) The expression of p-JAK1 and p-STAT3 in NPC and adjacent normal tissues were observed by immunohistochemical analysis. Results showed that expression levels of p-JAK1 and p-STAT3 were accumulated in tumor tissues. (b); after being transfected with miR-429 inhibitor, si-MSC-AS1, and si-JAK1, western blot analysis was performed to evaluate the changes in p-JAK1 and p-STAT3 expression. The expression of p-JAK1 (c) and p-STAT3 (d) significantly declined in si-MSC-AS1 + miRNA-ctrl and si-MSC-AS1 + miR-429 inhibitor + si-JAK1 group. NS: no significant difference, , , and . (e) The tumor growth and metastasis-related proteins were detected by western blot analysis. (f) The expression of MMP2, MMP9, Cyclin D1, and c-myc was significantly reduced in si-MSC-AS1 + miRNA-ctrl and si-MSC-AS1 + miR-429 inhibitor + si-JAK1 group. NS: no significant difference; .

(a)

(b)

(c)

(d)

(e)

(f)