miR-302a-3p Promotes Radiotherapy Sensitivity of Hepatocellular Carcinoma by Regulating Cell Cycle via MCL1

Figure 4

miR-302a-3p enhanced radiotherapy sensitivity of HCC cells by regulating cell cycle via MCL1. (a) Venn diagram of predicted mRNAs of miR-302a-3p and downregulated differential mRNAs; (b) MCL1 expression in radiation-sensitive and radiation-resistant tissues of HCC patients; (c) schematic diagram of the binding between MCL1 and miR-302a-3p sequences predicted by starBase; (d) binding relationship between miR-302a-3p and MCL1 verified by RIP experiment; (e) MCL1 mRNA expression of HepG2/RR cells in different treatment groups; (f) cell viability of HepG2/RR cells treated for different days with 8 Gy radiation dose; (g) cell cycle distribution of HepG2/R cells treated with 8 Gy radiation dose; (h) the expression of cyclins in HepG2/RR cells. vs. (mimic-NC + oe-NC), ^# vs. (mimic-NC+oe-MCL1).

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