A Novel 5-Methylcytosine- and Immune-Related Prognostic Signature Is a Potential Marker of Idiopathic Pulmonary Fibrosis

Figure 3

The construction of 5-methylcytosine and immune-related prognosis signature (m5CPS). (a) Sixty-three genes were identified as candidate genes for m5CPS. m5C-CEGs: m5CRGs coexpressed genes; PRGs: prognosis-related genes; IRGs: immune-related genes. (b) The least absolute shrinkage and selection operator (LASSO) coefficient profiles of the 63 candidate genes. The coefficient profile plot was produced against the log (lambda) sequence in the LASSO model. The optimal parameter (lambda) was selected. (c) Coefficients of six genes in m5CPS. (d) Differential expression levels of some of the six genes between the healthy group (the smaller fan-shaped region) and the IPF group (the larger fan-shaped region). (e) Coexpression relationship of six genes in the healthy group (the top panel) and the IPF group (the bottom panel); the Spearman correlation coefficient was used in this panel. , , .

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