Diagnostic and Prognostic Nomograms for Lung Metastasis in Triple-Negative Breast Cancer

Table 4

Univariate and multivariate Cox analyses of lung metastasis in patients with TNBC.

	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Age, years
≤40
41-60	1.382 (0.864-2.211)	0.177
>60	1.532 (0.972-2.414)	0.066
Tumour size, cm
≤5
5.1-10	1.191 (0.922-1.539)	0.180
>10	1.061 (0.768-1.466)	0.719
Race
White
Black	0.888 (0.529-1.491)	0.654
Other	0.907 (0.690-1.191)	0.481
Grade
I
II	1.146 (0.275-4.771)	0.851
III	0.673 (0.167-2.711)	0.578
IV	0.943 (0.172-5.158)	0.946
Histological type
8500
Other	1.407 (1.054-1.878)	0.021	1.424 (1.061-1.910)	0.019
T stage
T1
T2	1.359 (0.783-2.361)	0.276
T3	1.412 (0.808-2.470)	0.226
T4	1.335 (0.781-2.284)	0.291
N stage
N0
Nx	1.153 (0.864-1.539)	0.333
Surgery
No
Yes	0.553 (0.436-0.701)	<0.001	0.619 (0.485-0.790)	<0.001
Radiotherapy
No
Yes	0.830 (0.309-2.231)	0.712
Chemotherapy
No
Yes	0.399 (0.308-0.517)	<0.001	0.360 (0.273-0.474)	<0.001
Bone metastasis
No
Yes	1.487 (1.152-1.919)	0.002	1.386 (1.060-1.812)	0.017
Brain metastasis
No
Yes	1.970 (1.414-2.747)	<0.001	1.810 (1.281-2.558)	<0.001
Liver metastasis
No
Yes	1.833 (1.424-2.358)	<0.001	2.050 (1.576-2.667)	<0.001
Insurance
No
Yes	0.739 (0.452-1.209)	0.228
Marital status
No
Yes	0.676 (0.532-0.857)	0.001	0.665 (0.522-0.849)	0.001