Population Pharmacokinetics of Enteric-Coated Mycophenolate Sodium in Children after Renal Transplantation and Initial Dosage Recommendation Based on Body Surface Area

<div>Percentage of toxicity under different dosing regimens of enteric-coated mycophenolate sodium from simulation. Different colored lines represent patients with different body surface areas (BSA). The toxicity threshold of area under the concentration-time curve (AUC) of mycophenolic acid is 60 mg·h/L (over 12 hours after last dose, AUC<sub>0-12h</sub>), 120 mg·h/L (over 24 hours after last dose, AUC<sub>0-24h</sub>), and 240 mg·h/L (over 48 hours after last dose, AUC<sub>0-48h</sub>). (a) One dose every 8 hours (q8h). (b) One dose every 12 hours (q12h). (c) One dose every 16 hours. (d) One dose every 24 hours (qd). (e) One dose every 48 hours (qod). (f) One dose every 12 hours (different dosing amounts in the morning and the evening).</div>

Computational and Mathematical Methods in Medicine

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Figure 6

Figure 6: Population Pharmacokinetics of Enteric-Coated Mycophenolate Sodium in Children after Renal Transplantation and Initial Dosage Recommendation Based on Body Surface Area 

Figure 6 | Population Pharmacokinetics of Enteric-Coated Mycophenolate Sodium in Children after Renal Transplantation and Initial Dosage Recommendation Based on Body Surface Area 