[Retracted] Implications of Human Antimicrobial Peptide Defensin Beta-1 in Clinical Oral Squamous Cell Carcinoma Patients via an Integrated Bioinformatics Approach

Figure 8

The involvement of the DEFB1 gene in tumor immunity of OSCC. (a) Results regarding the correlation between DEFB1 expression and tumor immune infiltrating cells. (A) Lollipop plot showing the correlation between DEFB1 expression and 24 TIICs in OSCC. (B) Scatter plots showing the significant positive correlation between DEFB1 expression and 3 types of TIICs (i.e., B cells, mast cells, and Th17 cells) and the significant negative correlation between DEFB1 expression and 6 types of TIICs (i.e., Tgd, macrophages, T helper cells, Tem, Th2 cells, and NK cells). (b) Results regarding the correlation between DEFB1 expression and 15 ICGs in OSCC tumor samples. (A) The heat map showing the expression pattern of 15 ICGs in OSCC; (B) scatter plots showing the statistically significant correlation between DEFB1 expression and several genes (HAVCR2, CD276, BTLA, CD70, CD40, CD47, and TNFSF14).

(a) Correlation between DEFB1 and TIICs

(b) Correlation between DEFB1 and ICGs