[Retracted] Implications of Human Antimicrobial Peptide Defensin Beta-1 in Clinical Oral Squamous Cell Carcinoma Patients via an Integrated Bioinformatics Approach
Table 4
The correlations between overall survival and mRNA expression of DEFB1 analyzed by univariate and multivariate Cox regression.
Characteristics
Total ()
Univariate analysis
Multivariate analysis
HR (95% CI)
value
HR (95% CI)
value
T stage (T3 & T4 vs. T1 & T2)
318
1.363 (0.971-1.913)
0.074
2.111 (1.195-3.730)
0.010
N stage (N1 & N2 & N3 vs. N0)
314
1.320 (0.955-1.824)
0.092
1.321 (0.800-2.183)
0.277
M stage (M1 vs. M0)
311
2.621 (0.365-18.838)
0.338
Age (>60 vs. ≤60)
328
1.320 (0.954-1.826)
0.094
1.058 (0.658-1.702)
0.816
Gender (male vs. female)
328
0.908 (0.648-1.273)
0.576
Race (Asian & Black or African American vs. White)
318
1.532 (0.880-2.667)
0.131
Smoker (yes vs. no)
322
1.248 (0.845-1.844)
0.265
Clinical stage (Stage III & Stage IV vs. Stage I & Stage II)
318
1.282 (0.889-1.848)
0.183
Alcohol history (yes vs. no)
320
1.045 (0.740-1.475)
0.804
Histologic grade (G3 & G4 vs. G1 & G2)
320
1.252 (0.862-1.820)
0.238
Radiation therapy (no. vs. yes)
294
1.663 (1.164-2.377)
0.005
2.012 (1.195-3.385)
0.008
Primary therapy outcome (PD & SD vs. PR & CR)
277
5.472 (3.540-8.457)
<0.001
3.647 (2.174-6.119)
<0.001
Lymphovascular invasion (yes vs. no)
238
1.698 (1.141-2.529)
0.009
1.788 (1.091-2.930)
0.021
Lymph node neck dissection (no. vs. yes)
326
1.462 (0.964-2.216)
0.074
2.004 (0.847-4.742)
0.114
Anatomic neoplasm subdivision (floor of mouth vs. oral tongue)
186
1.471 (0.937-2.307)
0.093
Anatomic neoplasm subdivision (oral cavity vs. oral tongue)
197
1.161 (0.766-1.761)
0.482
Anatomic neoplasm subdivision (base of tongue vs. oral tongue)
148
1.004 (0.493-2.048)
0.990
Anatomic neoplasm subdivision (buccal mucosa vs. oral tongue)
147
0.965 (0.474-1.965)
0.922
Anatomic neoplasm subdivision (alveolar ridge vs. oral tongue)
