[Retracted] Implications of Human Antimicrobial Peptide Defensin Beta-1 in Clinical Oral Squamous Cell Carcinoma Patients via an Integrated Bioinformatics Approach
Table 5
The parameters of the all predicted outcomes in ROC curves. These parameters include area under the curves (AUC), confidence interval (CI), cutoff value, sensitivity, specificity, positive predictive value, negative predictive value, and Youden index.
Predicted outcomes
AUC
CI
Cutoff value
Sensitivity
Specificity
Positive predictive value
Negative predictive value
Youden index
Clinical status (tumor vs. normal)
0.758
0.682-0.835
7.08
0.626
0.844
0.976
0.18
0.47
T stage (T3 & T4 vs. T1 & T2)
0.499
0.434-0.564
8.079
0.214
0.829
0.667
0.398
0.044
N stage (N1 & N2 & N3 vs. N0)
0.559
0.495-0.623
6.018
0.483
0.667
0.559
0.596
0.15
Clinical stage (Stage III & Stage IV vs. Stage I & Stage II)
0.534
0.466-0.603
5.631
0.367
0.778
0.808
0.326
0.145
Histologic grade (G3 & G4 vs. G1 & G2)
0.566
0.483-0.648
4.915
0.333
0.849
0.377
0.823
0.183
Gender (male vs. female)
0.544
0.477-0.610
4.154
0.194
0.931
0.863
0.342
0.125
Race (Asian & Black or African American vs. White)
0.498
0.394-0.602
6.712
0.533
0.552
0.11
0.919
0.085
Age (>60 vs. ≤60)
0.536
0.473-0.599
7.42
0.341
0.755
0.608
0.506
0.096
Smoker (yes vs. no)
0.471
0.401-0.541
9.097
0.072
0.943
0.773
0.272
0.015
Alcohol history (yes vs. no)
0.595
0.529-0.661
7.046
0.681
0.524
0.746
0.444
0.204
Anatomic neoplasm (alveolar ridge & base of tongue & buccal mucosa & floor of mouth & hard palate & oral cavity vs. oral tongue)
0.524
0.460-0.588
5.706
0.374
0.714
0.679
0.415
0.089
Primary therapy outcome (PD & SD vs. PR & CR)
0.525
0.421-0.629
7.428
0.385
0.728
0.188
0.879
0.113
Radiation therapy (no. vs. yes)
0.478
0.411-0.546
6.754
0.578
0.453
0.406
0.623
0.03
Lymphovascular invasion (yes vs. no)
0.54
0.462-0.619
7.712
0.84
0.274
0.346
0.789
0.114
Lymph node neck dissection (no vs. yes)
0.614
0.523-0.706
5.763
0.533
0.677
0.209
0.901
0.211
OS (overall survival) event (dead vs. alive)
0.567
0.505-0.630
6.862
0.647
0.486
0.513
0.621
0.133
DSS (disease-specific survival) event (dead vs. alive)
0.546
0.476-0.616
5.025
0.28
0.822
0.4
0.729
0.101
PFI (progression-free survival) event (dead vs. alive)
