Research Article

[Retracted] Efficacy of Glucocorticoids and Glucocorticoid-Induced Hyperglycaemia in Renal Disease: A Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of interventions and populations at baseline and end of treatment in included RCTs.

RCTsThe primary diseaseDrugsBaseline characteristicsFollow-up monthsTreatment groupControl group
Treatment groupControl groupSample sizesDRFSample sizesDRF

Ronald 2006IgANPrednisone 60 mg/m2 every other day for 3 months, and then 40 mg/m2 every other day for 9 months, and then 30 mg/m2 every other day for 12 monthsPlaceboAge<40; renal biopsy showing IgAN; eGFR>50 ml/min per 1. 73m2; UPCR≥1. 0 g/g or moderate proteinuria, UP/C ratio ≥0. 5plus renal biopsy changes24302294
lv 2009IgANPrednisone 0. 8 to 1. 0 mg/kg/d, for 8 weeks, then the dose was tapered by 5 to 10 mg every 2 weekCilazapril aloneRenal biopsy showing IgAN; age18~65years; urine protein excretion of 1 to 5 g/d; eGFR≥30 mL/min24331307
Fellström2017IgANTRF-budesonide 16 mg/d and 8 mg/dayPlaceboPersistent proteinuria (UPCR ≥0·5 g/g or proteinuria ≥0·75 g/day); eGFR≥45 mL/min)951(8 mg/d)
49(16 mg/d)
0500
lv 2017IgANMethylprednisolone 0. 6-0. 8 mg/kg/d, then tapered by 8 mg/d each monthPlaceboProteinuria≥1 g/d and eGFR of 20~120 mL/min6 ~ 8136812620
Rauen, T. 2015IgANMethylprednisolone, administered intravenously at a dose of 1 g per day for 3 days at the start of months 1, 3, and5; oral prednisolone at a dose of 0. 5 mg per kilogram per 48 hours on the other daysSupportive careAge 18~70 year; proteinuria level above 0. 75 g/d; impaired renal function(eGFR 60-90 mL/min)655<218022
Rauen, T. 2018IgANMethylprednisolone, administered intravenously at a dose of 1 g per day for 3 days at the start of months 1, 3,and5; oral prednisolone at a dose of 0. 5 mg per kilogram per 48 hours on the other daysSupportive careGFR>60 ml/min655125416
Shoji 2000IgANPrednisolone 0. 8 mg/kg/day and tapering to 10 mg q. o. d. 1 yearDypiridamole 300 mg/dayProteinuria less than 1. 5 g/day; plasma creatinine concentrations<1. 5 mg/dl. Age 15 and 55 years.1211080