A Risk Score Signature Consisting of Six Immune Genes Predicts Overall Survival in Patients with Lower-Grade Gliomas

Table 3

Univariate or multivariate Cox regression analysis of clinicopathological features of LGGs associated with OS.

Characteristics	Total ()	Univariate analysis			Multivariate analysis
		Hazard ratio (95% CI)	value		Hazard ratio (95% CI)	value
Diagnosis age	461
≧50	145	Reference
<50	316	0.320 (0.220-0.465)	<0.001		0.407 (0.239-0.695)	<0.001
Gender	422
Female	186	Reference
Male	236	1.134 (0.769-1.673)	0.525
Grade	422
II	199	Reference
III	223	3.323 (2.163-5.103)	<0.001		2.567 (1.410-4.672)	0.002
IDH1 status	248
Mutant	189	Reference
Wild-type	59	4.927 (3.009-8.067)	<0.001		2.465 (1.238-4.907)	0.010
IDH2 status	286
Wild-type	274	Reference
Mutant	12	1.121 (0.351-3.579)	0.847
Codel 1p/19q	285
False	200	Reference
True	85	1.249 (0.755-2.067)	0.386
TERT promoter status	284
Wild-type	156	Reference
Mutant	128	0.953 (0.586-1.551)	0.848
TP53 status	286
Mutant	146	Reference
Wild-type	140	0.818 (0.505-1.324)	0.414
IRSS	461	3.172 (2.559-3.932)	<0.001		1.565 (1.052-2.329)	0.027

CI: confidence interval; IDH: isocitrate dehydrogenase; IRSS: immune risk score signature; TP53: tumor protein p53; TERT: telomerase reverse transcriptase.