[Retracted] miR-29b Regulates Lung Cancer Progression by Downregulating FEM1B and Inhibiting the FOX01/AKT Pathway

Figure 6

The effect of miR-29b expression on the downstream molecules in the signaling pathway. (a) RT-PCR showed that the expression level of HIF-1α, Sirt1, and AKT was decreased when miR-29b was overexpressed, while the level of TNF-α and FOX01 was increased when miR-29b was overexpressed. The siFEMB1 reversed this phenomenon. (b) The results of WB showed that when miR-29b was overexpressed, the expression levels of SMAD3 and Sirt3 were decreased and the TNF-α, VEGF, and FOX01 were increased. And the overexpression of FEM1B augments this phenomenon. (c) The expression ability of downstream molecular pathway factors in the supernatant of ELISA cells. , comparison between the miR-29b group and NC-A549 group; , comparison between the si-FEM1B and NC-NCI-H1792 group.

(a)

(b)

(c)