A SuperLearner Approach to Predict Run-In Selection in Clinical Trials

Table 1

Baseline characteristics, stratified by trial (A or B) and treatment (Placebo or Verum). Continuous variables are expressed in terms of I., II. (median), and III. quartiles while categorical ones with frequencies and absolute values.

Variables	Valid cases	Trial A		Trial B
		Placebo ( =54)	Verum ( =66)	Placebo ( =70)	Verum ( =67)
Age (years)	253	59/63/69	57/63/66	60/65/69	59/65/71
Body mass index	257	26/27/27	24/26/27	26/28/30	25/28/30
Gender: male	257	30%(16)	20%(13)	23%(16)	21%(14)
Height (cm)	257	160/165/173	163/166/170	154/160/165	154/160/166
Weight (kg)	257	66/71/79	65/70/75	64/69/77	63/70/77
Therapy responder	257	50%(27)	62%(41)	49%(34)	55%(37)