A SuperLearner Approach to Predict Run-In Selection in Clinical Trials

Table 3

Predictive performance statistics. The sentence “X to Y” (where X is trial A or trial B and Y is the other trial) indicates the performance of an algorithm trained on study X and tested on study Y (only on the indicated arm).

	Sens	Spec	Acc	PPV	NPV	AUC
A to B Placebo	0.611	0.529	0.571	0.579	0.563	0.658
B to A Placebo	0.370	0.778	0.574	0.625	0.553	0.630
A to B Verum	0.700	0.541	0.612	0.553	0.690	0.693
B to A Verum	0.760	0.634	0.682	0.559	0.813	0.763

Sens = sensitivity; Spec = specificity; Acc = accuracy; PPV=Positive Predictive Values; NPV=Negative Predictive Values; AUC = Area Under Curve.