[Retracted] Gluconeogenesis Alteration and p53-SIRT6-Fox01 Signaling Adaptive Regulation in Sheep from Different Grazing Periods

Figure 6

Schematic diagram of gluconeogenesis regulation in sheep raised in different grazing periods. The rate of gluconeogenesis was regulated by several enzymes, including PEPCPK, PC, G6P, and GLUT2. FOX01 plays a crucial role in gluconeogenesis by promoting the liver’s expression of PEPCK and G6P. p53 and SIRT6 regulate gluconeogenesis by controlling the expression of Fox01, and INSR regulates the expression of FOX01 by increasing the phosphorylation of PI3K and AKT. The ellipses marked in red color indicate the upregulated parameters, while the black dotted lines indicate that INSR did not regulate the expression of FOX01 via activating the PI3K pathway in the gluconeogenesis pathway.