Comparison of Different Furosemide Regimens in the Treatment of Acute Heart Failure: A Meta-Analysis

Table 1

Basic information of included literature and risk of bias assessment.

Study/year	Country	Sample size	Design	Dose of daily furosemide (mg)	Duration of interventions (hours)	Outcomes used in meta-analysis	Risk of basis
Makhoul/1997 [16]	Israel	20	Single-centre RCT	cIV: iIV: (divided in 3 doses)	24	Total urine output in 24 h	Low risk
Allen/2010 [10]	USA	41	Single-centre RCT	cIV: iIV: (divided in 2 doses)	48	Changes in weight loss; Length of hospital stay; Total urine output in 72 h	Uncertain risk
Thomson/2010 [12]	USA	56	Single-centre RCT	cIV: iIV:	100	Changes in weight loss	Uncertain risk
						Length of hospital stay
						Total urine output in 24 h
						Mortality
Felker/2011 [11]	USA+Canada	308	Single-centre RCT	cIV: iIV: (divided in 2 doses)	72	Changes in weight loss; Length of hospital stay; Total urine output in 72 h; Mortality	Uncertain risk
Shah/2014 [15]	India	60	Single-centre RCT	cIV: iIV: 100 (divided in 2 doses)	48	Length of hospital stay; Mortality	High risk
Yayla/2015 [14]	Turkey	29	Single-centre RCT	cIV: 160; iIV: 160 (divided in 2 doses)	48	Changes in weight loss; Length of hospital stay	Uncertain risk
Palazzuoli/2014 [9]	Italy	82	Single-centre RCT	cIV: iIV:	112	Changes in weight loss; Length of hospital stay; Total urine output in 24 h; Changes in BNP; Mortality	Uncertain risk
Palazzuoli/2015 [8]	Italy	58	Single-centre RCT	cIV: iIV: (divided in 2 doses)	120	Changes in weight loss; Total urine output in 24 h; Changes in BNP	Low risk
Ragab/2018 [17]	Egypt	40	Single-centre RCT	cIV: 120/240; iIV: 120/240 (divided in 3 doses)	24	Mortality	Uncertain risk
Zheng/2021 [13]	China	81	Single-centre RCT	cIV: 160/200; iIV: 160/200	72	Changes in weight loss; Length of hospital stay; Total urine output in 72 h; Changes in BNP	Uncertain risk

Note: cIV: continuous intravenous; iIV: intermittent intravenous.