Dysregulation of Circadian Clock Genes Associated with Tumor Immunity and Prognosis in Patients with Colon Cancer

Figure 2

Construction and evaluation of the effectiveness of a prognostic signature. (a) LASSO coefficients for PRGs. Each curve represents a CCG. (b) 1000-fold crossvalidation of variable selection in LASSO regressions. (c) A significant survival benefit for low-risk CRC patients. (d, e) KM plotter analysis demonstrated that CRC patients with higher risk score had a shorter DFS time with an AUC value of 0.75, 0.71, and 0.841 for the 1-year, 3-year, and 5-year DFS, respectively.

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