Dysregulation of Circadian Clock Genes Associated with Tumor Immunity and Prognosis in Patients with Colon Cancer

Figure 6

Distinct characteristics of immunogenicity of the CRC subtypes. (a) Tumor-infiltrating lymphocyte inflation among CRC subtypes was analyzed by using RNA expression data. (b) The expression levels of 8 immune checkpoint targets, which are critical for immunological control, were also evaluated, including SIGLEC15, CD274, HAVCR2, PDCD1LG2, LAG3, PDCD1, CTLA4, and TIGIT. (c) The MSI levels in CCG-related subtypes were analyzed.

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