Integrative Bioinformatics Analysis Reveals That miR-524-5p/MEF2C Regulates Bone Metastasis in Prostate Cancer and Breast Cancer

Figure 1

Identification of DE-miRNAs and DEGs related to cancer bone metastasis. (a) Clustered heat map of 1555 DEGs in GSE137842. Red: significantly upregulated genes; blue: significantly downregulated genes. (b) Differentially expressed volcano plots in GSE137842. Red dots: significantly upregulated; green dots: significantly downregulated; and black dots: no significant differences. (c) Clustered heat map of 833 DEGs in GSE32269. Red: significantly upregulated genes; blue: significantly downregulated genes. (d) Differentially expressed volcano plots in GSE32269. Red dots: significantly upregulated; green dots: significantly downregulated; and black dots: no significant differences. (e) Clustered heat map of 88 DE-miRNAs in GSE26964. Red: upregulated genes; blue: downregulated genes. (f) Differentially expressed volcano plots in GSE26964. Red dots: significantly upregulated; green dots: significantly downregulated; and black dots: no significant differences. (g) The common DEGs from GSE32269 and GSE137842 involved in prostate cancer bone metastasis and breast cancer bone metastasis by Venny 2.1.0. (h) List of the common DEGs from GSE32269 and GSE137842.

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