Integrative Bioinformatics Analysis Reveals That miR-524-5p/MEF2C Regulates Bone Metastasis in Prostate Cancer and Breast Cancer

Figure 3

The landscape of mRNA–miRNA interactions and PPI networks. (a) mRNA–miRNA interaction network. The graphic visualization uses different shapes representing different gene types: oval represents mRNA, and square represents miRNA. Different colors represent different gene expressions: blue represents downregulated genes, and red represents upregulated genes. (b) Differential expression of MEF2C in bone metastatic and nonbone metastatic prostate and breast cancers. The expression of miR-524-5p in bone metastatic and nonbone metastatic prostate cancer. (c) Protein–protein interaction (PPI) network of DEGs. The globules represent proteins, and the line between the globules represents the interaction between the two proteins.

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