Detection of the Content of Two Coumarins, IM and ISOIM, and Their Mechanism of Action on Colitis Rats in Angelica albicans

Table 5

Pharmacokinetic properties of IM and ISOIM after oral administration of Angelica albicans to normal and experimental-based TNBS-treated rat.

Properties	Normal rat		TNBS-treated rat
	0.5 g/kg	1 g/kg	0.5 g/kg	1 g/kg
IM	59	61	65	56
(min)	54	72	113	127
(min)	94	201	27	118
(ng/mL)	11860	23889	5196	24845
AUC0 →  ∞; MRT (min)	121	127	172	187
ISOIM	63	78	88	68
(min)	72	67	120	144
(min)	72	128	21	71
(ng/mL)	9445	17778	4197	17881
AUC0 →  ∞; MRT (min)	143	145	204	225

denotes half-life, represents time to attain peak concentration, signifies plasma concentration peak, →AUC_{0 ∞} is the area in plasma concentration, MRT means mean residence time, represents comparison of dosage treated normal rats.