Research Article

Effectiveness and Safety of Saccharomyces Boulardii for the Treatment of Acute Gastroenteritis in the Pediatric Population: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of 12 included literatures.

AuthorStudy designSample sizeAge rangeDuration of diarrhea
(h)
Duration of hospitalization
(days)
Persistency of diarrhea on day 1Persistency of diarrhea on day 3Diarrhea frequency on day 3Adverse event
InterventionControlInterventionControlInterventionControlInterventionControlInterventionControlInterventionControlInterventionControl

Das et al. [17]RCT30303 months to 5 years60(51-67)89(68-95)31014NANANANA
Riaz et al. [18]RCT54543 months to 5 years49.55(25.82-73.27)66.34(27.07,95.81)NANA1321101515.92 ± 13.43NANA
Dinleyici et al. [19]RCT2201434 months to 4 years60.4 (37.3-83.5)78.4(57.5-99.3)2001306982NANANANA
Billoo et al. [20]RCT50502 months to 12 years82(45.3-99.2)92(81.3-112.1)NANA109354.4 ± 3.05NANA
Cetina-sauri et al. [21]RCT65659 months to 20 monthsNANANANA10198143.63 ± 2.53NANA
Hafeez et al. [22]RCT50513 months to 60 monthsNANANANANANANANA5.73 ± 3.07NANA
Villarruel et al. [23]RCT44443 months to 2 years147.84(48-312)112.8(48-240)NANA2230923NANANANA
Kurugöl
et al. [24]
RCT1001003 months to 7 years112.8(50.4-172.8)132(55.2-208.8)1838824NANANANA
Grandy et al. [25]RCT25271 months to 23 months58(18-92)84.5(23.4-112.4)NANANANANANANANA
Bhat et al. [26]RCT40406 months to 5 yearsNANANANA3 ± 2.5NANA