Identification of Drug-Disease Associations Using a Random Walk with Restart Method and Supervised Learning

Table 1

Average AUC value of various diseases based on the random walk with restart method and three PPI networks BioGrid, HPRD, and STRING.

Disease classification based on MeSH	Number of diseases	Average AUC
Viral diseases C02	2	0.70467
Tumor C04	16	0.764632
Musculoskeletal diseases C05	5	0.748488
Digestive system diseases C06	9	0.760698
Respiratory diseases C08	2	0.68288
Nervous system diseases C10	9	0.62232
Eye diseases C11	2	0.83772
Male genitourinary system C12	1	0.81407
Cardiovascular disease C14	11	0.66685
Blood and lymphatic system C15	4	0.876637
Skin and connective tissue diseases C17	5	0.675556
Nutritional and metabolic diseases C18	6	0.734407
Endocrine system diseases C19	2	0.87446
Immune system diseases C20	4	0.62869