Research Article

[Retracted] Melatonin Attenuates Cisplatin-Induced Ototoxicity via Regulating the Cell Apoptosis of the Inner Ear

Figure 3

Melatonin attenuates cisplatin-induced apoptosis in HEI-OC1 cells. (a) The morphological characteristics of HEI-OC1 cells were compared using the TUNEL assay. The green fluorescence within the nucleus represented DNA breakage. Cells in the cisplatin group display obvious apoptotic features. Fewer cells show these apoptotic characteristics in the cisplatin exposure after melatonin pretreatment group, . (b) TUNEL assay showed a significant increase in the apoptosis rate of the cisplatin group. After melatonin pretreatment, the apoptosis rate decreased, .
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