[Retracted] circKMT2E Protect Retina from Early Diabetic Retinopathy through SIRT1 Signaling Pathway via Sponging miR-204-5p

Figure 2

Differential expression of circRNAs in diabetic retinopathy tissues. (a) The scatter plot of circRNA expression of the retinal tissues from diabetes mellitus (DM) and control groups. The middle black line indicates that the DM and normal control groups present no significant difference. circRNAs beyond the top black line or under the bottom black line signpost >2-fold alterations. The red spots disclose augmented circRNAs, and the green spots reveal diminished circRNAs in the DR group in contrast to the control group (). (b) The volcano plot of the circRNAs with remarkable differential expression between two groups. The vertical green lines represent 2.0-fold (log2 scaled) augmented and diminished changes. The horizontal green line refers to a value of 0.05 (−log10 scaled). The red spots represent circRNAs with remarkable differential expression (, ). (c) A number of 1063 circRNAs are significantly differentially expressed with ≥2-fold changes () in the DM group in contrast to the control group. There are 142 significantly upregulated circRNAs and 921 significantly downregulated circRNAs, including 198 novel circRNAs (red). (d) A number of 1063 circRNAs were probed to having a significant changed expression between two groups, and 14 circRNAs that presented more than 5-fold difference were delivered in this figure. The circRNAs with high expression were red-colored, while circRNAs with low expression were green-colored.

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