[Retracted] circKMT2E Protect Retina from Early Diabetic Retinopathy through SIRT1 Signaling Pathway via Sponging miR-204-5p

Figure 6

It seems circKMT2E can activate the SIRT1 signaling pathway by the sponge function to miR-204-5p. (a) The structure of circKMT2E located between the fourth and fifteenth exons of the KMT2E gene. (b) The assumed binding sites of miR-204-5p on circKMT2E. (c) Detailed annotation of the predicted binding site sequence between circKMT2E and miR-204-5p. The “2D Structure” column displays the combining sequence of circKMT2E and miR-204-5p. The “Local AU” shows the upstream and downstream of 30 nucleotides of the seed sequence. The “Position” column exhibits the possible situation of miRNA response elements on circRNA sequence. (d) miR-204-5p possesses binding site for SIRT1.

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