Analysis of Adverse Reactions of Aspirin in Prophylaxis Medication Based on FAERS Database

Table 3

The top 10 adverse event reports associated with using aspirin for prophylaxis from the FAERS database (January 2004 to June 2021).

Reactions	Indication		ROR (95% CI)	PRR (95% CI, )	BCPNN (IC-2SD)	EBGM (EBGM05)
Melaena	Prophylaxis	101	1.55 (1.28, 1.89)	1.55 (1.35, 1.75, 19.08)	0.62 (0.6)	1.55 (1.38)
Duodenal ulcer	Prophylaxis	48	2.29 (1.72, 3.04)	2.29 (2.01, 2.57, 33.38)	1.15 (1.11)	2.28 (2.04)
Gastritis erosive	Prophylaxis	46	3.29 (2.46, 4.4)	3.29 (3, 3.58, 70.1)	1.64 (1.59)	3.26 (3.02)
Gastric ulcer hemorrhage	Prophylaxis	42	2.29 (1.69, 3.11)	2.29 (1.99, 2.6, 29.16)	1.15 (1.11)	2.28 (2.03)
Blood loss anemia	Prophylaxis	33	1.54 (1.09, 2.16)	1.54 (1.2, 1.88, 5.63)	0.59 (0.56)	1.53 (1.25)
Duodenal ulcer hemorrhage	Prophylaxis	21	2.06 (1.34, 3.16)	2.06 (1.63, 2.49, 10.29)	0.97 (0.91)	2.05 (1.69)
Dyspnoea at rest	Prophylaxis	13	1.78 (1.03, 3.07)	1.78 (1.24, 2.33, 3.69)	0.75 (0.69)	1.78 (1.32)
Urinary tract discomfort	Prophylaxis	9	13.46 (6.9, 26.25)	13.46 (12.79, 14.13, 87.65)	2.56 (2.35)	12.91 (12.35)
Erosive duodenitis	Prophylaxis	7	2.43 (1.15, 5.1)	2.43 (1.68, 3.17, 4.48)	1.04 (0.94)	2.41 (1.79)
Naevus flammeus	Prophylaxis	5	8.1 (3.33, 19.69)	8.1 (7.21, 8.99, 23.73)	1.87 (1.66)	7.91 (7.16)
Total		325