Analysis of Adverse Reactions of Aspirin in Prophylaxis Medication Based on FAERS Database

Table 4

The top 10 adverse event reports associated with using aspirin for thrombosis prophylaxis from the FAERS database (January 2004 to June 2021).

Reactions	Indication		ROR (95% CI)	PRR (95% CI, )	BCPNN (IC-2SD)	EBGM (EBGM05)
Melaena	Thrombosis prophylaxis	127	1.95 (1.64, 2.33)	1.95 (1.78, 2.13, 57.64)	0.95 (0.93)	1.95 (1.8)
Duodenal ulcer	Thrombosis prophylaxis	31	1.48 (1.04, 2.1)	1.48 (1.12, 1.83, 4.26)	0.54 (0.5)	1.47 (1.18)
Microcytic anemia	Thrombosis prophylaxis	25	3.59 (2.42, 5.32)	3.58 (3.19, 3.98, 43.51)	1.69 (1.63)	3.55 (3.22)
Lip erosion	Thrombosis prophylaxis	22	3.85 (2.53, 5.86)	3.85 (3.42, 4.27, 42.94)	1.76 (1.69)	3.81 (3.46)
Vascular stent thrombosis	Thrombosis prophylaxis	22	3.99 (2.62, 6.07)	3.99 (3.57, 4.41, 45.67)	1.81 (1.73)	3.95 (3.6)
Mucosal erosion	Thrombosis prophylaxis	21	3.86 (2.51, 5.94)	3.86 (3.43, 4.29, 41.12)	1.76 (1.69)	3.82 (3.46)
Nikolsky’s sign	Thrombosis prophylaxis	18	4.02 (2.53, 6.41)	4.02 (3.56, 4.49, 37.42)	1.78 (1.7)	3.98 (3.59)
Hematoma muscle	Thrombosis prophylaxis	16	8.02 (4.88, 13.17)	8.02 (7.52, 8.51, 88.91)	2.48 (2.36)	7.83 (7.41)
Vascular stent stenosis	Thrombosis prophylaxis	8	3.58 (1.78, 7.19)	3.58 (2.88, 4.28, 12.25)	1.47 (1.35)	3.55 (2.97)
Thalamus hemorrhage	Thrombosis prophylaxis	8	3.13 (1.56, 6.28)	3.13 (2.43, 3.83, 9.46)	1.33 (1.23)	3.11 (2.53)
Total		298