Research Article

Exploring the Antiovarian Cancer Mechanisms of Salvia Miltiorrhiza Bunge by Network Pharmacological Analysis and Molecular Docking

Table 2

KEGG pathways.

NoTerm ValueGenes

1PI3K-Akt signaling pathway5.88E-15GSK3B, CDKN1A, ITGB3, RELA, EGFR, PIK3CG, CASP9, CCND1, MYC, AKT1, MAPK1, MCL1, HSP90AA1, INSR, IL2, VEGFA, IL4, IL6, CDK4, CDK2, BCL2, MDM2, MET, TP53, and BCL2L1

2T cell receptor signaling pathway2.19E-14IL10, GSK3B, JUN, FOS, MAPK14, TNF, IL2, PIK3CG, RELA, IL4, NFKBIA, CD40LG, IFNG, CDK4, AKT1, and MAPK1

3TNF signaling pathway6.21E-14JUN, EDN1, FOS, PTGS2, MAPK14, TNF, MMP9, PIK3CG, RELA, ICAM1, NFKBIA, CASP7, IL6, CASP3, AKT1, and MAPK1

4HIF-1 signaling pathway2.67E-13CDKN1A, EDN1, NOS2, INSR, STAT3, EGFR, PIK3CG, RELA, VEGFA, IL6, IFNG, ERBB2, BCL2, AKT1, and MAPK1

5Apoptosis1.30E-11NFKBIA, CASP9, CASP7, CASP3, BCL2, XIAP, AKT1, TNF, TP53, RELA, PIK3CG, and BCL2L1

6Viral carcinogenesis8.09E-11RB1, CDKN1A, JUN, STAT3, PIK3CG, RELA, NFKBIA, CCNA2, CCND1, CDK4, CASP3, CHEK1, CDK2, MDM2, MAPK1, PRKACA, and TP53

7FoxO signaling pathway4.08E-10IL10, CDKN1A, INSR, STAT3, MAPK14, EGFR, PIK3CG, IL6, CCNB1, CCND1, CDK2, MDM2, AKT1, and MAPK1

8Prolactin signaling pathway1.29E-09GSK3B, CCND1, STAT3, MAPK1, AKT1, FOS, MAPK14, ESR1, RELA, ESR2, and PIK3CG

9Cell cycle2.1E-09RB1, GSK3B, CDKN1A, PCNA, CCNA2, CCNB1, CCND1, CDK4, MYC, CHEK1, CDK2, MDM2, and TP53

10Estrogen signaling pathway2.4E-09HSP90AA1, JUN, MMP2, MAPK1, AKT1, FOS, PRKACA, ESR1, MMP9, EGFR, ESR2, and PIK3CG

11Thyroid hormone signaling pathway1.2E-08CASP9, GSK3B, CCND1, MYC, ITGB3, MDM2, MAPK1, AKT1, PRKACA, ESR1, TP53, and PIK3CG

12p53 signaling pathway1.4E-08CASP9, CDKN1A, CCNB1, CCND1, CDK4, CASP3, CHEK1, CDK2, MDM2, and TP53

13MicroRNAs in cancer8.1E-08CDKN1A, ITGB3, STAT3, PTGS2, MMP9, EGFR, VEGFA, CCND1, MYC, CASP3, ERBB2, MDM2, BCL2, MET, TP53, and MCL1

14Focal adhesion6.3E-07GSK3B, JUN, ITGB3, XIAP, EGFR, PIK3CG, VEGFA, CCND1, ERBB2, BCL2, AKT1, MAPK1, and MET

15Toll-like receptor signaling pathway8.048E-07NFKBIA, IL6, JUN, MAPK1, AKT1, FOS, MAPK14, TNF, RELA, and PIK3CG

15 KEGG pathways that were highly correlated with ovarian cancer. The pathways were arranged according to Values, and the genes contained in the pathways were listed.