[Retracted] Grading Evaluation of Cardiotoxicity in Patients with Breast Cancer Treated with Adjuvant Paclitaxel Anthracycline/Cyclophosphamide Chemotherapy: A Meta-Analysis

Table 1

Characteristics of study included in the meta-analysis.

Author	Published year	Country	Regimes sequence	Age median	Observation period	Setting	Cardiac toxicities
Dennis J Slamon	2011	USA	A+C→T(N=1073)	unclear	24W; 1 year	Unclear	1) LVEF decrease ≥10 points (n=114); 2)CHF(n=7); 3) Cardiac death(n=0)
Pooja P. Advani	2015	USA	A+C→T(N=205)	49	9.2 year	Unclear	1) LVEF decrease ≥10 points (n=42); 2) LVEF decrease 15 ≥points (n=19); 3) LVEF decrease to below the LLN (n=13); 4) Cardiac death(n=2)
Patricia A. Ganz	2017	USA	A+C→T(N=220)	unclear	1) 18months(n=110); 2) 8.8 years (n=110)	Unclear	1) LVEF decrease ≥10% to <50% (n=3); 2) LVEF decrease ≥10% to <50%(n=5)
C. Hudis	1999	USA	A→T→C(N=42)	46	48 months	Metastatic	1) cardiac toxicities (n=0)
Roy E. Smith	2002	USA/Canada	A+C+T(N=89)	30-78	36.5months	Metastatic	1) LVEF decrease ≥20% (n=21); 2) CHF(n=3)
Edward H.Romond	2005	USA	A+C→T(N=625)	unclear	2 years	Non-metastatic	1) CHF(n=4); 2) Cardiac death(n=1)
Edward H. Romond	2012	USA	A+C→T(N=743)	49	7 years	Unclear	1) CHF(n=9); 2) Cardiac death(n=1)
Maysa M. Abu-Khalaf	2007	USA	A→T→C(N=85)	56.7	7 years	Metastatic	1) LVEF decrease <50% (n=7); 2) CHF(n=1); 3) Cardiac death(n=0)
Jean-marc A.Nabholtz	1997	USA	T→A→C(N=52)	49	2 months	Metastatic	CHF(n=1)
Elizabeth Tan-Chiu	2005	USA	A+C→T(N=814)	unclear	5 years	Non-metastatic	1) CHF(n=4); 2) Cardiac death(n=1)
J.M. Nabholtz	2001	France	T→A+C(N=40)	18-70	32 months	Metastatic	1) CHF(n=2)
D. Khayat	2001	France	A+C→T(N=44)	18-75	40.4 months	Metastatic	1) CHF(n=2)