GPC1 Is Associated with Poor Prognosis and Treg Infiltration in Colon Adenocarcinoma

Table 1

Univariate and multivariate Cox hazard regression analyses of COAD in TCGA.

Variables	Total ( vs. )	Univariate analysis		Multivariate analysis
		HR (95% CI)	value	HR (95% CI)	value
Age (>60 vs. ≤60)	477 (194 vs. 283)	1.610 (1.052-2.463)	0.028	2.553 (1.538-4.241)	<0.001
Gender (female vs. male)	477 (226 vs. 251)	1.101 (0.746-1.625)	0.627
Race (Asian vs. Black or African-American vs. White)	306 (11 vs. 63 vs. 232)	0.927 (0.208-4.133)	0.921
T stage (T1&T2 vs. T3&T4)	476 (94 vs. 382)	3.072 (1.423-6.631)	0.004	3.471 (1.066-11.305)	0.039
N stage (N0 vs. N1&N2)	477 (283 vs. 194)	2.592 (1.743-3.855)	<0.001	0.409 (0.152-1.097)	0.076
M stage (M0 vs. M1)	414 (348 vs. 66)	4.193 (2.683-6.554)	<0.001	2.264 (1.309-3.915)	0.003
Pathologic stage (I&II vs. III&IV)	466 (267 vs. 199)	2.947 (1.942-4.471)	<0.001	4.772 (1.528-14.900)	0.007
GPC1 ()	477	1.339 (1.114-1.609)	0.002	1.225 (1.002-1.497)	0.048