Elucidation of the Key Therapeutic Targets and Potential Mechanisms of Marmesine against Knee Osteoarthritis via Network Pharmacological Analysis and Molecular Docking

<div>Identification of the therapeutic targets of marmesine in the treatment of OA. (a) The intersection with marmesine- and OA-related genes. (b) Heat map of the 60 intersection genes in GSE98918 dataset. The purple group is the OA group, while the dark green group is the control group. The downregulated genes are exhibited in blue, and upregulated genes are showed in red. (c) Volcano diagram of 60 intersection genes in marmesine-related genes. The blue dots represent the downregulated genes, and the red dots represent the upregulated genes. (d) PPI network of 60 intersection genes.</div>

Computational and Mathematical Methods in Medicine

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Figure 3: Elucidation of the Key Therapeutic Targets and Potential Mechanisms of Marmesine against Knee Osteoarthritis via Network Pharmacological Analysis and Molecular Docking 

Figure 3 | Elucidation of the Key Therapeutic Targets and Potential Mechanisms of Marmesine against Knee Osteoarthritis via Network Pharmacological Analysis and Molecular Docking 