Elucidation of the Key Therapeutic Targets and Potential Mechanisms of Marmesine against Knee Osteoarthritis via Network Pharmacological Analysis and Molecular Docking

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Target proteins</td><td class="align_center" colspan="5">Binding energy (kcal/mol)</td></tr><tr class="thead"><td class="align_center">EGFR</td><td class="align_center">CASP3</td><td class="align_center">MMP9</td><td class="align_center">PPARG</td><td class="align_center">MAPK1</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td class="align_left">Marmesine</td><td class="align_center">-6.18</td><td class="align_center">-6.3</td><td class="align_center">-5.11</td><td class="align_center">-5.35</td><td class="align_center">-7.13</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Binding energies of marmesine to the hub target proteins.</div>

Computational and Mathematical Methods in Medicine

tab2

Table 2

Table 2: Elucidation of the Key Therapeutic Targets and Potential Mechanisms of Marmesine against Knee Osteoarthritis via Network Pharmacological Analysis and Molecular Docking 

Table 2 | Elucidation of the Key Therapeutic Targets and Potential Mechanisms of Marmesine against Knee Osteoarthritis via Network Pharmacological Analysis and Molecular Docking 