High DHCR7 Expression Predicts Poor Prognosis for Cervical Cancer

Table 3

Associations with overall survival (OS), progression-free interval (PFI), disease-specific survival (DSS), and clinicopathologic characteristics in TCGA patients (a) Cox regression. (b) Multivariate survival model after variable selection.

Characteristics	Total ()	OS		PFI		DSS
		HR (95% CI)	value	HR (95% CI)	value	HR (95% CI)	value
(a) Cox regression
T stage (T2 and T3 and T4 vs. T1)	241	1.846 (1.045-3.260)	0.035	1.656 (0.976-2.812)	0.062	2.047 (1.068-3.926)	0.031
N stage (N1 vs. N0)	193	2.695 (1.358-5.349)	0.005	1.983 (0.986-3.990)	0.055	3.303 (1.446-7.541)	0.005
Clinical stage (stage II and stage III and stage IV vs. stage I)	297	1.429 (0.896-2.280)	0.134	1.308 (0.821-2.084)	0.258	1.608 (0.941-2.749)	0.082
Primary therapy outcome (CR vs. PD and SD and PR)	217	0.074 (0.040-0.138)	<0.001	0.126 (0.074-0.216)	<0.001	0.059 (0.030-0.116)	<0.001
Radiation therapy (yes vs. no)	304	1.153 (0.681-1.951)	0.596	1.288 (0.754-2.200)	0.354	1.772 (0.891-3.522)	0.103
Histological type (squamous cell carcinoma vs. adenosquamous)	304	1.010 (0.530-1.926)	0.976	0.778 (0.433-1.397)	0.400	0.956 (0.467-1.958)	0.901
Menopause status (post vs. pre and peri)	231	1.275 (0.744-2.185)	0.376	1.091 (0.640-1.861)	0.749	1.233 (0.678-2.243)	0.493
Histologic grade (G3 and G4 vs. G1 and G2)	272	0.889 (0.527-1.502)	0.661	1.594 (0.967-2.627)	0.067	0.955 (0.530-1.720)	0.877
Smoker (yes vs. no)	261	1.470 (0.900-2.401)	0.124	0.998 (0.613-1.623)	0.993	1.309 (0.747-2.295)	0.347
Birth control pill history (yes vs. no)	157	0.677 (0.326-1.404)	0.294	0.938 (0.495-1.776)	0.844	0.705 (0.314-1.581)	0.396
Keratinizing squamous cell carcinoma present (yes vs. no)	304	1.395 (0.813-2.394)	0.227	1.077 (0.657-1.765)	0.769	1.789 (0.938-3.412)	0.077
Age (>50 vs. <=50)	304	1.317 (0.825-2.101)	0.248	1.612 (1.012-2.568)	0.044	1.333 (0.780-2.278)	0.292
Height (>160 vs. <=160)	261	1.092 (0.633-1.883)	0.752	0.830 (0.489-1.410)	0.491	0.915 (0.498-1.683)	0.776
Weight (>70 vs. <=70)	275	0.736 (0.446-1.214)	0.230	0.645 (0.390-1.066)	0.087	0.802 (0.453-1.420)	0.450
Race (Asian and Black or African American vs. White)	259	0.841 (0.427-1.658)	0.618	1.066 (0.553-2.057)	0.848	0.770 (0.344-1.724)	0.526
PIK3CA status (Mut vs. WT)	286	1.011 (0.599-1.707)	0.967	0.994 (0.589-1.679)	0.983	1.097 (0.606-1.989)	0.759
DHCR7 (high vs. low)	304	1.758 (1.088-2.841)	0.021	2.224 (1.352-3.657)	0.002	2.258 (1.271-4.013)	0.005
(b) Multivariate analysis
T stage (T2 and T3 and T4 vs. T1)	241	0.812 (0.312-2.111)	0.669			0.947 (0.229-3.918)	0.940
N stage (N1 vs. N0)	193	2.670 (1.094-6.515)	0.031			2.605 (0.998-6.801)	0.050
Primary therapy outcome (CR vs. PD and SD and PR)	217	0.185 (0.068-0.506)	0.001	0.151 (0.056-0.411)	<0.001	0.126 (0.042-0.381)	<0.001
Age (>50 vs. <=50)	304			0.543 (0.216-1.363)	0.193
DHCR7 (high vs. low)	304	2.973 (1.177-7.510)	0.021	2.517 (1.082-5.856)	0.032	3.207 (1.194-8.611)	0.021