[Retracted] circ_0041795 Induces YAP1 Upregulation to Accelerate the Progression of Diabetic Retinopathy through Binding to miR-589-5p

Figure 1

Knockdown of circ_0041795 promoted proliferation but suppressed apoptosis, inflammation, and oxidative stress in HG-treated ARPE-19 cells. (a) circ_0041795 level was assayed by RT-qPCR after treatment of NG or HG in ARPE-19 cells. (b) circ_0041795 and GAPDH levels were examined using RT-qPCR in ARPE-19 cells. (c–l) ARPE-19 cells were treated with NG, HG, HG+si-NC, and HG+si-circ_0041795. (c) circ_0041795 was quantified by RT-qPCR. (d) Cell viability was detected by CCK-8 assay. (e) Cell proliferation was assessed by EdU assay. (f, g) Cell apoptosis was evaluated by flow cytometry. (h) PCNA and Bax protein levels were measured by western blot. (i, j) IL-6 and TNF-α concentrations were determined by ELISA. (k, l) SOD activity and MDA level were analyzed by commercial kits. Student’s -test was used in (a), and two-way ANOVA was used in (b/h), and one-way ANOVA was used in other graphs. , , and .

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